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bpsA [2018-11-23 16:56:12]
type III polyketide synthase
function
polyketide synthesis
product
type III polyketide synthase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]Gene
Coordinates
2,316,956 → 2,318,053
The protein
Catalyzed reaction/ biological activity
synthesis of triketide pyrones from long-chain fatty acyl CoA thioesters as starter substrates and malonyl-CoA as an extender substrate [Pubmed|19465653]Structure
[PDB|4JAO] (from Mycobacterium tuberculosis, 34% identity)[SW|Localization]
cell membrane (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]-[gene|6BAF5763249305F27326F941A34956396B3F8C99|bpsB]
description
[Pubmed|19465653]
view in new tabBiological materials
Mutant
MGNA-A875 (bcsA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/875 NBRP B. subtilis, Japan]BKE22050 (''[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]''::''erm'', available in the BGSC and in [SW|Jörg Stülke]'s lab) [pubmed|28189581]GP1820 (''[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]''::''erm'', available in [SW|Jörg Stülke]'s lab)BKE22050 (Δ[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE22050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCGATCACCTCTTTGCA, downstream forward: _UP4_AGCTGGGAAAAGGGGGCCTGBKK22050 (Δ[gene|7D90F7AF49BAD6A95731BF805991DEBBBCAFA46C|bpsA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK22050 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGCGATCACCTCTTTGCA, downstream forward: _UP4_AGCTGGGAAAAGGGGGCCTGReferences